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A major weapons supplier to Cobra, Destro takes a great personal interest in the success of the evil organization's undertakings. This is a man who understands power, and the ruthless actions that are often necessary to acquire it and keep it. He heads to the far north with the Baroness to take over a complex communications array, as part of a Cobra plan to control every country on the planet. His technological understanding of the system serves him well, but he finds himself challenged by the stubborn ingenuity of the G.I. Joe team.
Destro is a member of Cobra in G.I. Joe: Resolute. It's unknown if he retains the high position that he had in the organization in other versions of the franchise, but his relationship with the Baroness is left intact.
In the miniseries, Destro and the Baroness are part of a subplot in which they have taken a team of scientists hostage. Roadblock, Gung-Ho and Stalker have to rescue them before Destro starts killing them.
- Unlike other animated versions of Destro, this one has a noticeable Scottish accent.
- Destro was voiced by Eric Bauza.
- The original script called for Destro to have a rocket launcher concealed in his (possibly bionic) right arm. He would have unveiled it after being captured at the H.A.A.R.P. Facility, making good his escape while leaving Baroness behind. The weapon was seen on an early model sheet leaked to the public, and the scene was storyboarded, but it was trimmed for time before being animated.